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Targeting CD47 represents a novel immunotherapeutic strategy and holds great potential to improve the antitumor immune responses mediated by the macrophages. This approach has shown positive results for the treatment of B-cell malignancies, acute leukemia, ovarian and colorectal cancer. CD47 is a ubiquitously expressed immunoregulatory protein best known for its so-called 'don't eat me' function that prevents phagocytic removal of healthy cells by the immune system. Many types of cancer present high levels of this don't eat me signal on their surface, thereby disrupting anti-cancer immune responses. The CD47/signal regulatory protein alpha (SIRPα) axis is a critical regulator of myeloid cell activation and serves a broader role as a myeloid-specific immune checkpoint.

Cd47 immunotherapy

GD2-based immunotherapy has become standard of care for neuroblastoma patients but has not yet mediated clinical benefit for those with osteosarcoma. New immunotherapy possible for canine cancer blocking a cell surface protein called CD47 might be a potent treatment for a wide variety of human cancers. Nov 13, 2020 ALX148 showcased favorable safety and elicited objective responses when combined with trastuzumab, pembrolizumab, and multiagent Apr 14, 2020 Therapeutic CD47 blockade enhances T cell responses and Evaluation of Anti- CD47 Immunotherapy against Established HIV-1 Infection in Mar 6, 2020 revealing that gut bacteria can penetrate tumor cells and boost the effectiveness of an experimental immunotherapy that targets the CD47 Keywords. CD47, SIRPα, immunotherapy, tumor microenvironment, pediatric cancer, innate immune system, checkpoint inhibitor, phagocytosis Mar 30, 2020 antibodies to block CD47, a “don't eat me” signal on cancer cells, presently in development;; and immunotherapy drugs that block the PD-1 CD47, Do not eat me signal, Macrophage, Phagocytosis, Immunotherapy. Cells of the innate and adaptive arm of the immune system including macrophages, Tumor cells express CD47, which can interact with the macrophages' SIRPα in the TME is well demonstrated in tumor progression and immunotherapy [5, 14].

CD47, an immune checkpoint known as the “don’t eat me” signal, is highly expressed on the surface of various cancers, allowing cancer cells to send inhibitory signals to macrophages and impede phagocytosis and immune response. In this study, we hypothesized that blocking the “don’t eat me&rdquo 2018-12-11 The CD47-SIRPα signaling axis functions as an innate immune checkpoint that inhibits phagocytosis in phagocytes and has been implicated as a promising target for cancer immunotherapy.

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Inhibitors of the CD47-SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p … 2020-08-01 Introduction: CD47 is an anti-phagocytic ('don't eat me') signal overexpressed in many malignant diseases. It acts as myeloid immune checkpoint and thus has prognostic and therapeutic implications. Areas covered : This review presents and discusses the currently available data on the prognostic role and therapeutic value of CD47 in gastrointestinal tumors.

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generates T2 contrast on MR scans that can serve as an imaging biomarker for monitoring responses to CD47 immunotherapy Mohanty et al.

CD47 kan inhibera makrofagaktivitet och därigenom minska inflammation och and the anti-gal antibody in xenotransplantation and in cancer immunotherapy. cd47-antigener · cd46-antigener · cd45-antigener · cd44-antigener sublingual immunotherapy · subcellulära fraktioner · sjuksköterskestuderande DE / CD47 GY 10% 8 0.3% ComStage STOXX(r) Europe ETF Series Solutions - Loncar Cancer Immunotherapy ETF CNCR.O / CNCR US oslo Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with cd47 blocking immunotherapy. CD47 kan binda med signalreglerande protein a (SIRPα) på makrofager för att överföra Blockering av CD47 på CTC: er kan främja fagocytos av makrofager. Dessutom var tvungen expression av PD-L1 och CD47 vid The introduction of systemic cancer immunotherapy in clinical practice CD36, CD36/CD47/α6β1-integrin, CD14/TLR2/TLR4, and FPR2 display species using immunotherapy, the overexpression of Aβ-degrading enzymes to Interaktioner mellan SIRP a på fagocyter med CD47 leder till aktivering av Src-homologiinnehållande tyrosinfosfatas-1 Implications for Tumor Immunotherapy.
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Together, those findings raise the possibility that gut microbiota influence anti-CD47 immunotherapy through changing the local microenvironment, challenging the current gut immunity-initiated model. Our study iden- However, the antitumor efficacy of CD47-based immunotherapy relies on the near-complete blockade of CD47 in the tumor microenvironment (TME; Ingram et al., 2017).

Dec 11, 2019 Targeting CD47 could trigger macrophage-mediated elimination of between anti-angiogenic therapy and tumor immunotherapy [17,18,19].
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Haematologica, Volume 103, Issue 8 by Haematologica - issuu

Ther. offers a valuable resource for researchers in the cancer immunotherapy field, checkpoint regulation and develop safer and more effective immunotherapies. Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 Alex of Research på Immunicum, håller ett anförande på temat “CD47 and Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 på temat“CD47 and phosphatidylserine contribute to the interaction Cancer immunology, immunotherapy : CII - 2014-01-01 CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a AbbVie Strikes Deal for I-Mab Drug With a Potential Edge in CD47 immunotherapy developer and its lead CD47 inhibitor, magrolimab." Cancer Immunotherapy (CIMT) Annual Meeting, May 10 – 12, 2021.

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As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα).

To validate the impact of berberine on CD47 expression, DLBCL cells were treated with 30μM berberine for 0, 24 and 48 hours. The results revealed that CD47 was downregulated by berberine at a time-dependent manner (Figure 3A and B). To explore the upstream of CD47 in DLBCL, inhibitors of CD47-related upstream protein were applied to LY1 cells. NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy Colorized scanning electron micrograph of a cell (purple) infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity.